An Overall Trend of Headache Remission during COVID-19 Pandemic for Chinese Patients with Pre-existing Headache Highlights the Role of Family Supports (preprint)

Background: Impact of COVID-19 pandemic on Chinese patients with pre-existing headache remains unclear. The present study investigated the impact of COVID-19 pandemic on headache patients in China.Methods: A survey was conducted through an online survey platform from June 6, 2020. Demographic characteristics, PHQ-9 scores, ISI scores, COVID-19 questionnaires and headache profile section were included in the online questionnaires.Results: Eventually a total of 15,000 participants from China completed the online questionnaire. Among them, 2806 participants (18.71%) had preexisting headache disorders. Our analysis showed a reality of those participants with remission of headache duration (3.414±6.859 vs 4.033±7.325, P=0.000), headache days per month (1.788±2.989 vs 2.092±3.694, P=0.000), and headache intensity (4.110±1.609 vs 4.290±1.680, P=0.000), during COVID-19. Smoking (OR=1.397, 95% CI 1.090 to 1.790, P=0.008) and getting support from family members during the social isolation (OR=1.656, 95% CI 1.075 to 2.550, P=0.022) were the independent factors of remission in headache duration. Education level (OR=1.478, 95% CI 1.103 to 1.980, P=0.009) and having relative or acquaintance got COVID-19 (OR=0.643, 95% CI 0.458 to 0.902, P=0.011) were the independent factors of remission in headache severity. And participants living in Wuhan area, having COVID-19 symptoms or COVID-19 diagnosis and having relative or acquaintance got COVID-19 are more likely to get headache deteriorated.Conclusions: Participants presented an overall trend of headache remission during COVID-19. Family supports played an important role in headache remission.

Postmortem Tissue Proteomics Reveals the Pathogenesis of Multiorgan Injuries of COVID-19 (preprint)

Multiorgan injuries are a major complication of severe COVID-19; however, its pathogenesis is barely understood. Herein, we profiled the host responses to SARS-CoV-2 infection by performing quantitative proteomics of COVID-19 postmortem samples, and provided a comprehensive proteome map covering the protein alterations in eight different organs/tissues. Our results revealed that lung underwent the most abundant protein alterations mainly enriched in immune-/inflammation-related or morphology-related processes, while surprisingly, other organs/tissues exhibited significant protein alterations mainly enriched in processes related with organ movement, respiration, and metabolism. These results indicate that the major cause of lung injury was excessive inflammatory response, and subsequent intravascular thrombosis and pulmonary architecture/function destruction, while other organs/tissues were mainly injured by hypoxia and functional impairment. Therefore, our findings demonstrate the significant pathophysiological alternations of host proteins/pathways associated with multiorgan injuries of COVID-19, which provides invaluable knowledge about COVID-19-associated host responses and sheds light on the pathogenesis of COVID-19.